Migraine: Experimental Models and Novel Therapeutic Approaches

New therapeutic approaches for the prevention and treatment of migraine.

The management of patients with migraine is often unsatisfactory because available acute and preventive therapies are either ineffective or poorly tolerated. The acute treatment of migraine attacks has been limited to the use of analgesics, combinations of analgesics with caffeine, ergotamines, and the triptans. Successful new approaches for the treatment of acute migraine target calcitonin gen...

Novel Therapeutic Targets for Chronic Migraine

Andreou AP, Sprenger T, Goadsby PJ. Cortical spreading depression-evoked discharges on trigeminothalamic neurons. Headache. 2012;52:900. Monteith TS, Goadsby PJ, Shapiro RE. Eliminating the burden of chronic migraine and posttraumatic headache in military and civilian populations. Headache. 2012;52:869. Hoffmann J, Park JW, Storer RJ, Goadsby PJ. Magnesium and memantine do not inhibit nocicepti...

Kynurenine Metabolites and Migraine: Experimental Studies and Therapeutic Perspectives

Migraine is one of the commonest neurological disorders. Despite intensive research, its exact pathomechanism is still not fully understood and effective therapy is not always available. One of the key molecules involved in migraine is glutamate, whose receptors are found on the first-, second- and third-order trigeminal neurones and are also present in the migraine generators, including the do...

Novel Therapeutic Approaches for Neuroblastoma

Glioblastoma Multiforme: Novel Therapeutic Approaches

The current therapy for glioblastoma multiforme involves total surgical resection followed by combination of radiation therapy and temozolomide. Unfortunately, the efficacy for such current therapy is limited, and newer approaches are sorely needed to treat this deadly disease. We have recently described the isolation of bacterial proteins and peptides with anticancer activity. In phase I human...